The XRs aren’t manufactured in low doses, so I would sometimes just take a few “pellets” or “beads” to avoid getting the full dose – this seemed to work fairly well. Any references or sites to help me investigate this further? If you currently use Adderall (or have used it), did you prefer the IR (immediate-release) format or the XR (extended-release) format? If 12 hours isn’t enough relief, the IR (immediate-release) may be tacked onto the end of the 12 hours for antidepressant relief until a person falls asleep. Normani Is More Confident Than Ever Before, Filters, FaceTune, And Your Mental Health, ‘Fitness Helped Me Find Joy After Losing My Leg’, This content is created and maintained by a third party, and imported onto this page to help users provide their email addresses. Adderall XR is formatted in capsule form containing  pellets. For tutoring please call 856.777.0840 I am a recently retired registered nurse who helps nursing students pass their NCLEX. The dosage options for Adderall XR include: 5 mg, 10 mg, 15 mg, 20 mg, 25 mg, and 30 mg.  As you can tell, there are smaller increments between doses of the IR version. Hopefully I do, but who knows. LoL. Within these capsules, 50% of the pellets are immediate-release, and 50% are delayed-release. She even continued taking the drug while pregnant with her first child. However, you may notice the opposite at first. Dry drunk symptoms are largely behavioral. The amphetamine-class of ADHD medications includes Adderall (75% dextroamphetamine salts and 25% levoamphetamine salts), Dextroamphetamine, and Vyvanse … The combination of immediate and delayed release pellets results in a bimodal distribution of effect that could be achieved by simply taking 2 properly-timed immediate-release tablets. That said, Anderson also adds that depression itself can decrease sexual functioning, too, so it’s important to know what’s normal for you. So, if you were to take 30mg of Adderall IR, in XR dosage size, you would feel the effects of 30mg of Adderall all at once. The generic caused, apparently, to a possible allergic reaction due to “inactive ingredients” or “filler.” My RN prescribed the Brand Name – as medically necessary: the insurance that I have, Horizon, NJ Family Care approved because she deemed it necessary. This is not true with my personal experiences. It’s supposed to last 8-10 hours… It lasts me 4-5 hours. Extended stimulation for 12 hours leads to an extended crash and downregulation of dopamine receptors – something I wanted to avoid. Don't take Adderall IR with alcohol or illicit drugs. There’s no significant benefit associated with one version over the other; they both contain 75% dextroamphetamine and 25% levoamphetamine. Adderall IR is formatted in an immediate-release tablets. From having used my previous brands before this, I would take a 30mg tablet and within a half hour I would ALWAYS notice the onset of effects. I find I still need caffeine to stay awake, not nearly as much as without but I still need it. Weight gain is frequently talked about as a side effect of many antidepressants. The dreaded crash is there too… To me, moreso w/ the XR’s since the drug is constantly in you for the whole day, rather than a few hours. Among those looking to abuse Adderall, the immediate-release format may be slightly more popular. Both the IR and XR were helpful in treating my major depression, but at too high of doses, they seemed to induce an overly intense dopaminergic euphoria – which I was trying to avoid. You went on this medication for relief from depression or anxiety—but the strange truth is that sometimes, it can make these things worse. The Adderall XR version was engineered specifically to last up to 12 hours. Adderall XR can be purchased under the generic “amphetamine salt combo XR” – costing $75 to $140 for 30 pills. To find a psychiatrist to understand that because of the bypass, I do not have the digestive system to effectively utilize extended release medications (XR-ER)! Generally the greater the contrast between your “medicated state” and your “non-medicated state,” the more noticeable the crash. Due to the fact that the ingredient composition is the exact same in Adderall IR and XR, the side effects are likely to be the same. The capsules of the Adderall XR contain little beads, 50% of which are immediate-release (just like the “IR”) and 50% of which are delayed-release. With that kind of brand, I took 30mg and felt NOTHING. It uses traction to stretch your penis. And waited … and waited .. AND WAITED. While taking Adderall IR, I was functional and able to focus and my ADD symptoms seemed to have almost disappeared, plus I was considerably less anxious. I had no tolerance to amphetamines at the time, so a 60mg dose of Adderall IR after a 30mg dose before, that had no effect, should have ROCKED ME. They came straight out of the pharmacy, they had to be real, I trusted them. Taking them together can lead to unwanted and potentially dangerous side effects. That said, since both Adderall IR and XR contain the same ratio of mixed salts, the effect should be nearly identical. (so 7.5 mg IR up to three times a day). The Melatonin Side Effects You Should Know About, 7 Xanax Side Effects You Should Know About, 7 Plan B Side Effects You Should Know About, 7 Adderall Side Effects You Need To Know About. If I happen to forget, and ate something already, I wait a couple hours after eating to take them. I just started the IR so I don’t know if it’s truly working yet, but I’m gonna give it a month and see if I get the same results as the 20 mg XR. You would think there wouldn’t be any serious side effects because I was actually taking *less* of the drug, just in extended release form. So, in terms of dosage size of both the IR and XR forms wouldn’t be the same. Since I have the 20mg IR dosage sized pills, I can easily make my dosage sizes into multiples of 5mg. “What a combo, right! Cannabidiol (CBD) Side Effects & Adverse Reactions, L-Tyrosine Side Effects & Adverse Reactions (List), Armour Thyroid Side Effects & Adverse Reactions (List), Remeron (Mirtazapine) Withdrawal Symptoms + How Long They Last, Capsule (50% immediate-release, 50% delayed-release), 5 mg, 7.5 mg, 10 mg, 12.5 mg, 15 mg, 20 mg, 30 mg. In terms of total efficacy, I do not think that one is better than the other, assuming that the pills/capsules contain the correct amounts. So I guess I could say they had some sort of effect on me… DROWSINESS. I don’t know why there is such a big difference for me but there is. Without crushing the beads within the capsules, they will not elicit any sort of any effect. I’ve been on Adderall IR for a while but have taken XR as well. He likely does better with amphetamines. I worked from the age of twelve without not having a job– this disorder– has been disabling. This site uses Akismet to reduce spam. I was recently diagnosed with ADD and prescribed Adderall IR. 70 mg Vyvanse lasts 4 hours. Those that only need short-term relief from ADHD symptoms may prefer to take the immediate-release IR version. Take doses at intervals of four to six hours. Anyway, around 2 hours later, after taking that first so-called 30mg Adderall IR pill, I had long since been back home. Tablets can be easily crushed, whereas those attempting to insufflate the capsules will have a more difficult time emptying and crushing the beads. And its structure is the basis for dozens of amphetamine-based drugs including Adderall (amphetamine), appetite suppressants, decongestants, antidepressants, and psychedelics like MDMA and mescaline. Individual preferences for one format over the other are usually due to the duration over which a person needs the psychostimulant effect. At first my doctor prescribed me the 20 mg of XR once a day and it only lasted for like 6 hours. I tried other routes of administration w/ them to NO AVAIL. Since most people do well on one type or the other, but not both, this outcome makes sense. Learn how your comment data is processed. But anyway… sorry for this being such a long response, but I hope y’all understood what I was intending and attempting to communicate. So it’s not like I ate or took anything that would inhibit, dull, or stop the effects of taking any Adderall that day. Actress Amanda Seyfried admitted not long ago on a podcast that she's been taking the antidepressant Lexapro for "years and years and years." I feel like I absorb it better and feel it works better for me. Certain types of … (I later found out that they were manufactured by Mallinkrodt Pharmaceuticals Inc.). Those with long school or work days may opt to take the XR version for 12 hours worth of relief. However, if you don’t always need a “second wind” after your first 4 to 6 hours, Adderall IR may be preferred. I had come to believe that I may have been given a placebo, and was stuck with them for at least 4 weeks. This is due to the fact that it’s far easier to crush up a tablet for insufflation, than it is to crush up the tiny pellets within the extended-release version. Powered by Lexicomp. This means you can take just one of the XRs and you should experience symptomatic reduction for the entire day. Taking them together can lead to unwanted and potentially dangerous side effects. Those taking high doses of the IR may find that they experience a noticeable crash after 4 hours, compared to a noticeable crash after 12 hours as would occur with the XR. Nearly 10 percent of patients who taking Lexapro for major depressive disorder experience dry mouth, the FDA reports. I have been on this dosage for 10 plus years. You may be able to find more information about this and similar content at piano.io, Watch Dr. P Squeeze A Pasta Machine Steatocystoma, The Best Air-Purifying Plants for a Healthier Home, ‘My Brain Tumor Online Group Was A Saving Grace’, Watch Dr. P Pop 'Green Caterpillars' From Cyst, 'I Started A Slack Channel For COVID Long Haulers', Why This Pregnant Doc Got The COVID-19 Vaccine, Watch Dr. P Squeeze 'Turkey Gravy' Stuffed Cyst. This side effect is most likely to hit during your first few weeks of taking the med. Off-label uses such as Adderall for depression as an antidepressant augmentation option may benefit more from the XR (extended-release) version due to the fact that it provides long-lasting relief. I did well on a combo of wellbutrin and Zoloft for many years but the generic forms … This may be somewhat of a placebo effect, but could also be due to absorption differences. Most docs prescribe a lower dose taken twice a day but still prescribe the EX. Common side effects associated with both versions include: appetite loss, diarrhea, dizziness, dry mouth, fever, headaches, insomnia, nausea, nervousness, stomach pain, vomiting, and weight loss. They are also way easier to break down into specific dosage sizes you may want. This intermittent or infrequent usage associated with the immediate-release version may result in less severe Adderall withdrawal symptoms. For 30 “brand name” pills of the extended-release format, most pharmacies will charge between $225 and $240. I talked to my therapist and he switched me to adderall IR. I have been on adderall the last couple years or so. “Many SSRI’s, including Lexapro, can cause a temporary decrease in appetite that lasts only for a short time,” says Anderson. Slight variations in side effects may be due to differences in absorption of the tablet-formatted IR or the capsule-formatted XR. I found that the XR gave me horrible headaches and made me really tired later in the day! Nearly 10 percent of patients who taking Lexapro for major depressive disorder experience dry mouth, the FDA reports. For me there really is a significant difference between the two. My problem with Vyvanse is that it only comes in extended relief. Or you may not know… they could be PLACEBO. Individuals that only need to focus for 4 to 6 hours may rather take the IR version and feel less drugged for the remainder of the day. The "mini-tablets" cannot be split or dissolved to make a liquid. I just feel better on the IR, it’s released all at once and lasts 4-5 hours and then I take another one. im on bupropion and i love it. Both Adderall IR and XR are approved for the treatment of ADHD and narcolepsy. Most users of Adderall have experienced what is commonly referred to as an Adderall crash. Thereafter, its efficacy is generally maintained for weeks, or perhaps months after the initial dosage with favorable results. Below is a recap of the similarities between Adderall IR and XR. The NLM notes some serious side effects are possible, like thoughts of hurting yourself or unusual behavior, anxiety, or seeing or hearing things that aren’t there. They can protest all they want. I have notice HUGE differences in the quality of different brands of Adderall. Unfortunately pellets cannot be “counted” due to the fact that you won’t know which are the immediate versus the delayed release. But extreme proposals like Waters “millennial project” will make it impossible for Democrats to run from this label during the 2020 Presidential campaign. Some speculate that Adderall XR may be slightly more popular than the IR due to the fact that it is newer and longer-acting. I take 25mg XR. So then the doctor made me take it twice a day and it worked very well. Now I was beside myself, not knowing what to do, about to flip out. Signs and Symptoms you have Low Testosterone. I took the first two with Lexapro, which was moderately effective mentally but seemed connected to significant weight gain. When under the influence of crack, users experience a heightened libido and increased stamina. Weekends or work days off when I do not need to focus as much and can give my body a break. If we’re talking strictly from a “pill count” perspective, “brand name” Adderall IR is a cheaper option. Some may prefer the smaller incremental increases of the IR dosing, while others may like the 25 mg option of the XR. Not to mention for some reason my body responds more to XR as opposed to IR. I have noticed a major decline in my desire for intimacy. There also shouldn’t be any significant differences in terms of side effects. I have tried many drugs before for my depression including ; Zoloft, celexa, lexapro, Effexor, viibryd, Trintellix and wellbutrin. Anyway the differences between Adderall IR and XR? That said, Adderall XR still is manufactured in six different dosing options, just one shy of the IR version. Yeah, I had the same heart/chest pain breathing problems plus severe fatigue and nausea, which I struggled with for over 2 years. I have not had a positive experience with the extended release, would really like to know the reason behind this. I work long hour days, so that’s why I need it. The good news? The likelihood of this (and other side effects) rises as you increase the dose. If you take 1 30mg Adderall XR capsule, within 30 – 60mins, as said above, but onset times may vary of course, you will feel the effects of 15mg Adderall IR’s strength, then up to 12 hours later, you will feel the effects of 15mg IR strength again. Lacking the duodenum, ilium etcetera makes XR or ER ineffectual (mostly) or the duration is dramatically shortened. That said, crashes aren’t thought to be more common with the IR compared to the XR or vice-versa. Suggestions for gradual tapering: If you are taking 20mg, 30mg, or 40mg (two 20mg capsules) per day, switch to brand-name Cymbalta or a generic containing tiny beads rather than mini-tablets. Those with these conditions may prefer to use one format of Adderall over the other, or may use a combination of both. Find patient medical information for Amphetamine Salt Combo (20mg) oral on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings. Take Adderall XR in the morning to avoid trouble sleeping. “I’ve had patients say they don’t even want to look at the long list [of potential side effects] because they feel they have everything described,” she says.Still, that's no reason not to take it: One study in 2014 noted that about 60 percent of patients say they had at least one side effect when taking an antidepressant. Throughout that day I think I used in upwards of 250mg of those pills trying to find a way to make them work and never did. Some may find that being medicated for a longer period of time throughout the day with the XR increases the severity and duration of the crash. At first, you may notice that your bathroom habits are a bit…different. However, you’ll notice that the drug delivers a “second wind” of effect after the immediate-release pellets are fully processed. I didn’t take anything that would deplete the level of dopamine recent to before that day, so there was ABSOLUTELY NO REASON why the medication should not have worked. I took the XR for one day like this and all through the day I had trouble breathing. This is a temporary “crash” in terms of both physical and mental energy that occurs when Adderall’s effect wears off. You, as a reader of this website, are totally and completely responsible for your own health and healthcare. Those taking the extended-release version (XR) may be medicated more throughout the day, and therefore may have an increasingly difficult time stopping the drug. Have you had menopause? The total duration of effect provided by Adderall XR is estimated to be approximately 12 hours, whereas that of Adderall IR is between 4 and 6 hours. I have been a nurse since 1997. Individuals with narcolepsy may find that Adderall XR doesn’t provide quite as long of relief as they need, and may take an Adderall IR for additional relief when the XR wears off. The most severe forms of ADHD often benefit from using prescription medication. So that being the reason why 1 30mg Adderall XR capsule is EQUIVALENT to 2 15mg Adderall IR pills/tablets. For whatever reason the capsules make my stomach produce too much acid which causes extreme chest pain and breathing problems and fatigue which all lessoned when I lowered my dosage, however it still remain until I went back on the pill form versus the capsules. The last thing you want is for a medication to put you in a weird head space. The pharmacy had to order the “brand,” so, I will pick it up on Monday. I saw a cardiologist which said I was in fantastic condition. This was likely due to the fact that low doses are available for the IR, and I was taking microdoses of 2.5 mg or 5 mg. You just want to call it a day. Lexapro (Escitalopram) vs Zoloft (Sertraline): Extensive Comparison. Some may argue that since the “IR” version is in tablet format, it is subject to greater abuse. Years after its initial approval, Shire Pharmaceuticals developed an “extended-release” format of the drug called “Adderall XR.”  This format of the drug was launched in 2001 as a means to provide extended relief from attentional-deficits spanning up to 12 hours. Have you noticed a change in your mood or just overall the way that you feel?. There may be some differences in severity and duration of withdrawal related to whether you took Adderall IR or XR. But Lexapro can cause dizziness or drowsiness. Delivery of the drug and how it’s processed matters, but just because the IR works better for you, does not mean that it will work better for someone else. Some individuals may resort to taking a combination of the XR, followed by an IR dose so that their only “crash” is a good night’s sleep. LoL. The IR was only $31 for a 30 day supply! So I guess different BRANDS of Adderall IR most certainly have different effects, and side effects, from other substances holding the pill together… binders and fillers and inactive ingredients, AMOUNT AND QUALITY of drug in the pills. (Your body varies in the amount of time it takes to process things.) To soothe your stomach, take Lexapro with food. Those taking the original version of Adderall (immediate-release) often would end up having to take multiple pills throughout the day due to the fact that the effect only lasted 4 to 6 hours. You can also subscribe without commenting. There will be significant individual differences in regards to whether you experience a crash after your Adderall wears off. Furthermore, should you want to “taper” or titrate your dosing downwards, there are bigger jumps in dosing increments of 5 mg with the XR version compared to 2.5 mg increments with the IR version. A number of people do this and the only answer is to take meds 2x a day. Otherwise known as “smart drugs” in some circles, these meds are typically amphetamines or methylphenidate. © MentalHealthDaily.com 2013-2019 | Privacy Policy | Legal Notice | Affiliate Disclosure, Provigil (Modafinil) vs. Adderall: Comparison, Vyvanse For Depression: Lisdexamfetamine As An Adjunct Treatment, Pantoprazole (Protonix) vs. Omeprazole (Prilosec), Lexapro (Escitalopram) vs. Prozac (Fluoxetine), Pregabalin (Lyrica) vs. Gabapentin (Neurontin). Like bed time. Taking a nap and finding time for physical activity can help you shake off the sleepy feeling, the Mayo Clinic advises. Some people claim to tolerate one format than the other, which is likely due to physiological differences in absorption of the beads within the XR compared to the tablet of the IR. Some individuals with ADHD may have a supply of both Adderall IR and XR to use based on how much cognitively-demanding work they’ll be doing. He told me to take a half of a tablet 2 to 3 times a day depending on what my day looks like. Understand that this is just my personal experience and preference for how I used the drug. This means that they have a high potential for abuse, are habit forming, and may result in dependence. One might start to exhibit a low tolerance for stress or behave impulsively, repeatedly engaging in unhealthy or risky behaviors. I get best effects from my medications this way. However, since it would require 2 Adderall IRs to elicit the same duration of effect as an Adderall XR, a more accurate comparison may be the cost of 60 IR pills to 30 XR pills. While on the Adderall XR version, I never noticed any problems with them being poor quality or placebo, but definitely side effects are different. Women's Health may earn commission from the links on this page, but we only feature products we believe in. The delayed-release pellets are comprised of a bead in the center of a drug layer, with an overcoating covered in a release-delaying polymer, covered with a second overcoating. Those taking the immediate-release (IR) version may not use the drug as frequently or on an intermittent basis. Adderall is a well-known medication used to treat ADHD that has been on the market since 1996. Finally, a doctor who looked at my chart and asked why I have been prescribed XR medications if I had gastric bypass – which requires immediate release medications! Anderson talks to her patients about GI side effects that may feel like a mild “stomach flu” with nausea and diarrhea. Not because one may give you a better buzz or sense of euphoria, but they are WAY easier to manage, and take as needed for immediate effects. So, went to a gastroenterologist, which was then that it was realized that what I had was dyspepsia which is nothing more then a stomach acid flare up cause by the medication being the XR version of Adderall. – although Adderall work much better for me I ended up switching to methylphenidate ER because Adderall did not offer a tablet form in the XR version. That said, there isn’t specific data in regards to whether Adderall IR or XR is the more popular format among general users. Neither version of the drug should be considered superior to the other. Why trust us? This means that as the first immediate-release pellets are “wearing off” the delayed-release pellets are just kicking in. Adderall IR (Immediate Release) lasts about the same amount of time. On Monday, 8 February 2016, I will begin taking “brand name adderall” immediate release. I already LOVE it so much more. 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