The issue of styrene and cancer has been a priority for IARC ever since an accumulation of leukaemia cases among employees in the American synthetic rubber industry was seen in the 1970s. En matière de prévention, il demeure important de savoir que le styrène est considéré comme «peut-être cancérogène pour l’homme» selon le Centre international de recherche contre le cancer. ScienceDaily. The predictive value of rodent carcinogenicity tests in the evaluation of human risks, Chemicals and cancer in humans: first evidence in experimental animals, Chemicals causally associated with cancers in humans and in laboratory animals: a perfect concordance, Lorenzo Tomatis and primary prevention of environmental cancer. (9) in 2010 likewise demonstrated significantly elevated risks in petrochemical workers exposed to styrene when data for all categories of non-Hodgkin’s lymphoma are combined (Standardized Incidence Ratio = 1.87, 95% CI = 1.01–2.99, based on 15 cases) (10). Styrene is on the Proposition 65 list because it can cause cancer. Published by Oxford University Press on behalf of the UK Environmental Mutagen Society. Styrene is the precursor … Have any problems using the site? IARC in 2002, nearly 10 years ago, concluded that the evidence was already considerable but not fully sufficient for causality (5). www.sciencedaily.com/releases/2018/05/180530113105.htm (accessed December 31, 2020). Hearing … In California this led to requirements for special product labelling, while EU countries do not have to label Roundup as a carcinogen. UPR Sector Group of Cefic 17 . In March, the 23 researchers in the WHO working group spent ten intensive working days in Lyon, where they had the task of reviewing and re-evaluating the carcinogenic risk based on the latest research on styrene exposure which includes epidemiological studies of humans together with animal experiments and what are known as mechanism studies. To understand … Styrene (/ ˈ s t aɪ r iː n /) is an organic compound with the chemical formula C 6 H 5 CH=CH 2.This derivative of benzene is a colorless oily liquid, although aged samples can appear yellowish.The compound evaporates easily and has a sweet smell, although high concentrations have a less pleasant odor. Cancer Studies in Humans The limited evidence for the carcinogenicity of styrene in humans is based on studies of workers exposed to styrene that showed (1) in-creased mortality from or incidence of cancer of the lymphohemato- poietic system and (2) increased levels of DNA adducts and genetic damage in lymphocytes from exposed workers. The conclusion that diets can play a role in lowering or increasing cancer … Styrene (vinyl benzene) is an economically important industrial chemical used in the synthesis and manufacture of polystyrene and hundreds of different copolymers, as well as numerous other industrial resins. This part of the study is published in Occupational and Environmental Medicine in the article 'Sinonasal adenocarcinoma following styrene exposure in the reinforced plastics industry'. There is also some evidence for increased risks of esophageal and pancreatic cancer among styrene-exposed workers. Butadiene or styrene or butadiene and styrene or else? In the research project, PhD student Mette Skovgaard Christensen, Henrik Kolstad and their research colleagues followed 73,036 employees who during the period 1968-2011 worked in one of the 456 small and medium-sized companies in Denmark that have used styrene in the production of e.g. We offer the following regional Styrene coverage to keep you informed of factors and developments affecting prices in the Europe Styrene marketplace.. Price reporting Price Reporting – More information about the price reports we publish on Styrene 0.75 0.01 0.76 Forced … Is that only an issue if the tv gets smashed or something? P.F.I. This has led to Germany forbidding the driving of older diesel cars in a number of cities. Questions? (2) recently reported cytogenetic and DNA damage in workers exposed to styrene and concluded their findings were supported by previous study results demonstrating genotoxicity associated with occupational exposure to styrene (e.g. For forty years, this has been the conclusion of researchers who have been unsure of whether there is an increased risk of cancer associated with styrene. Financial support for ScienceDaily comes from advertisements and referral programs, where indicated. However, a causal relationship between styrene exposure and cancer in humans is credible and is supported by the finding of DNA adducts and chromosomal aberrations in lymphocytes from styrene-exposed workers.’ The NTP conclusion that styrene is ‘reasonably anticipated to be a human carcinogen’ based on induced cancers… Le formaldéhyde, substance présente notamment dans les matières plastiques, et le styrène font désormais partie de la liste des produits cancérigènes. "We've tried to make it clear that a listing in the report doesn't necessarily mean that encountering that substance in any minute quantity means you'll get cancer," said NTP Associate Director John Bucher. For permissions, please e-mail: journals.permissions@oup.com. Many companies take measurements, but they are not publicly available. These collective carcinogenicity findings clearly support, predated and predicted styrene carcinogenicity in humans (14–21), as nearly one-third of known human carcinogens were first identified in long-term bioassays (22–25). Or view hourly updated newsfeeds in your RSS reader: Keep up to date with the latest news from ScienceDaily via social networks: Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. "That part of the study is primarily based on measurements that the Danish Working Environment Authority carried out a number of years ago, since the Danish Working Environment Authority has not carried out measurements of styrene over the past several years. No adequate human studies are available for styrene-7,8-oxide although this is the primary and active epoxide metabolite of styrene. We have therefore mapped the cancer incidence for those who worked in companies that used styrene in the production during the period 1968-2011," explains Henrik Kolstad on the background for what has ended up being the world's largest epidemiological study of styrene exposure in the reinforced plastics industry. Planning a summer barbecue this weekend or stocking up for Labor Day? All rights reserved. Does styrene cause cancer? New Device Detects Which Hand Gesture You Want to Make, Key Advance for Printing Circuitry on Wearable Fabrics, Luminescent Wood Could Light Up Homes of the Future, Research Lays Groundwork for Ultra-Thin, Energy Efficient Photodetector on Glass. Moreover, in the interests of public and occupational health, we suggest that authors be more cautious in their casual acceptance of industry papers and reviews of epidemiological study results related to occupational exposure to styrene (or other chemicals). © The Author 2011. Roughly 99% of the industrial resins produced from styrene can be grouped into six major categories: polystyrene (50%), styrene-butadiene rubber (15%), unsaturated polyester resins (glass reinforced) (12%), styrene-butadiene latexes (11%), acrylonitrile-butadiene-styrene (10%) and styrene-acrylonitrile (1%) (1). 96-09-3. "After 40 years in limbo: Styrene is probably carcinogenic." Views expressed here do not necessarily reflect those of ScienceDaily, its staff, its contributors, or its partners. "Clearly, the best place to study the possible health effects of styrene exposure is in the reinforced plasticsindustry, where no butadiene is involved. In its pure form, styrene has a sweet smell. Well there’s a new development around the health effects of styrene, that’s been hotly contested for years. Back-up Slides Styrene Exposure Scenarios . Budroni et al. The latter cover cause-effect studies based on biological material. Methods. Styrene officially linked to cancer. Aarhus University. (2), however, dismissed IARC’s Working Group evaluation in 2002 (5) by iterating from the 2009 Boffetta et al. The NTP independent Board was not swayed or particularly impressed with the analysis and conclusions of the Boffetta et al. The NTP conclusion that styrene is ‘reasonably anticipated to be a human carcinogen’ based on induced cancers, genotoxicity and mechanism is further bolstered by the 2010 case–control study in six European countries by Cocco et al. Long-term chemical carcinogenesis bioassays showed that styrene caused lung cancers in several strains of mice and mammary cancers in rats and styrene-7,8-oxide caused tumours of the forestomach in rats and mice and of the liver in mice. Sciences study of Styrene and cancer. There is also some evidence for increased risk of cancer in the pancreas or esophagus among some styrene … One of the reasons why the results carry a lot of weight with the WHO is that Kolstad and his colleagues have been able to compare the research data from the cancer patients with measurements of styrene exposure in the Danish reinforced plastics industry over time. Some scientists think it’s already over. Reasonably Anticipated to Be a Human Carcinogen. Issues, controversies, and uncertainties. After this stage, the information was linked with the Danish Cancer Register to assess the incidence of different types of cancer among the employees compared to the general population's risk of developing the same diseases. Styrene is an industrial chemical used to produce a number of different … The facilities have since closed but, when operational, manufactured boats using styrene … Elevated risks of lym-phohematopoietic cancer … The Factors That Do Increase Cancer Risk. Content on this website is for information only. Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Title: Styrene Cancer Warning Upheld. Government scientists effectively have seen just enough evidence to posit a link between styrene and cancer, but not enough for ironclad proof. He is pleased with the fact that we in Denmark are able to do something that no other country can: "The reason for my presence in the working group is our register-based research, which is unique throughout the world, and where the most recent styrene study shows the risk of acute myeloid leukaemia, a rare form of leukemia, is doubled. hide. About the United Kingdom Environmental Mutagen Society, http://ntp.niehs.nih.gov/?objectid=BD1A20B5-F1F6-975E-7CF8CBFACF0FC7EF, http://ntp.niehs.nih.gov/ntp/roc/twelfth/profiles/StyreneOxide.pdf, http://www.ehjournal.net/content/10/S1/S14, Receive exclusive offers and updates from Oxford Academic, Comparison of genotoxic potency of styrene 7,8-oxide with γ radiation and human cancer risk estimation of styrene using the rad-equivalence approach, Styrene monomer does not induce unscheduled DNA synthesis in the mouse liver following inhalation exposure. The issue of styrene and cancer has been a priority for IARC ever since an accumulation of leukaemia cases among employees in the American synthetic rubber industry was seen in the 1970s. Styrene is a colorless to yellow liquid that is highly flammable and evaporates easily. Don't take our word for it, click on the linked chapters to have a look at some actual pages from the book in PDF format. We offer the following regional Styrene analysis and news coverage to keep you informed of factors and developments affecting prices in the Styrene marketplace.. Price reporting Price Reporting – More information about the price reports we publish on Styrene However, a causal relationship between styrene exposure and cancer in humans is credible and is supported by the finding of DNA adducts and chromosomal aberrations in lymphocytes from styrene-exposed workers.’. Materials provided by Aarhus University. The move came in response to the results of a comprehensive study carried out by researchers from Aarhus University, along with new animal … Note: Content may be edited for style and length. Styrene is included in synthetic rubber, some insulation materials, disposable tableware, packaging and fiberglass plastic. In some studies, the risks increased with increasing measures of exposure, such as average exposure, cumulative exposure, or number of years since first exposure. Monographs are impartial research reports, which assess the strength of evidence for carcinogenic effects so that individual countries have a qualified basis for legislation. Title: Formaldehyde, Styrene Cancer Warning. Search for other works by this author on: Styrene. Just this week, the National Research Council (NRC) signed off on the National Toxicology Program’s decision to list styrene … "Possibly carcinogenic and should be investigated more closely." "But in the instance of styrene… Styrene has been classified by the International Agency for Research on Cancer (IARC) as Group 2A, probably carcinogenic to humans, based on limited human and sufficient animal evidence. Another example is the monograph that last year found that the herbicide glyphosate, better known as Roundup, can be carcinogenic. It's a handbook no modeler should be without. save. Lung Resection For Non-Small-Cell Lung Cancer - A New Risk Score To Predict Major Perioperative Complications. To further explore the relationship between work-related styrene exposure and cancer, NIOSH investigators compared styrene exposures to cancer deaths among 5,201 former workers in two boat-building facilities in Washington State. (6) styrene review paper ‘that no consistent increased risk of any cancer among workers exposed to styrene was found. Government Agency reviews also concluded that styrene and its major metabolite styrene-7,8-oxide (SO) are both mutagenic and clastogenic as well as carcinogenic (1,4). http://ntp.niehs.nih.gov/files/20081216SIRC.pdf (accessed June 20, 2011), Occupational exposure to solvents and risk of lymphoma subtypes: results from the Epilymph case-control study, Cancer incidence among petrochemical workers in the Porto Torres industrial area, 1990–2006, Cancer incidence among petrochemical workers in the Porto Torres industrial area, Styrene, styrene oxide, polystyrene, and beta-nitrostyrene/styrene carcinogenicity in rodents, Carcinogenicity and mechanistic insights on the behavior of epoxides and epoxide-forming chemicals, Chemicals studied and evaluated in long-term carcinogenesis bioassays by both the Ramazzini Foundation and the National Toxicology Program: in tribute to Cesare Maltoni and David Rall, Predicting chemicals causing cancer in animals as human carcinogens, Alleged misconceptions' distort perceptions of environmental cancer risks, Role of experimental and epidemiological evidence of carcinogenicity in the primary prevention of cancer, Identification of carcinogenic agents and primary prevention of cancer, Prevention versus chemophobia: a defence of rodent carcinogenicity tests, Long-term chemical carcinogenesis bioassays predict human cancer hazards. He is professor in occupational medicine, at the Department of Clinical Medicine at Aarhus University as well as Aarhus University Hospital. What about other health effects? Styrene is widely used in the manufacture of synthetic rubber, resins, polyesters and plastics. What is styrene? Chapter 1, The Case for Styrene… The World Health Organization’s International Agency for Research on Cancer (IARC) has now upgraded the cancer-causing status of the common plastic ingredient styrene. Standardized … review (6,7). There are no strong or consistent indications that styrene causes any form of cancer in humans. (8) who reported significantly elevated risks for B-cell non-Hodgkin’s lymphoma [odds ratio (OR) = 1.6; 95% confidence interval (CI) = 1.1–2.3] and for follicular lymphoma (OR = 2.6; 95% CI = 1.3–5.2) in relation to styrene exposure. 19 Styrene ES Results for FRP Manufacturing (industrial) Risk Characterisation Manufacturing Activity RCR inhalation RCR dermal RCR all routes RMMs Open mold - rolling, brushing, etc. Subsequent epidemiologic studies found styrene workers had increased mortality or incidences of lymphohematopoietic cancers (leukaemia or lymphoma or all), with suggestive evidence for pancreatic and esophageal tumours. "After 40 years in limbo: Styrene is probably carcinogenic." However, the types of lymphohematopoietic cancer observed in excess varied across different cohort studies, and excess risks were not found in all cohorts. Among others before, Teixeira et al. EcoWatch, July 29, 2014 July 30, 2014. Hence, based on both animal and human cancer studies and genotoxic findings including clastogenicity and DNA damage in workers as well as on other supportive and biologically plausible mechanistic results, styrene and styrene-7,8-oxide should be considered as presenting carcinogenic risks to humans, particularly for lymphatic/hematopoietic cancers. Share on Reddit; WeChat; Email; Print; To send an e-mail to multiple recipients, separate e-mail addresses with a comma, semicolon, or both. National Institute of Environmental Health Sciences, National Institutes of Health. Styrene found in plastic products is linked with leukemia and nasal cancer risk, revealed research Aarhus University, Denmark. Experience shows that countries respond differently to the warnings of the monographs. Out of the more than 70,000 people included in the research project, we found 25 cases of acute myeloid leukaemia, where you would statistically expect to find 10," says Professor Henrik Kolstad with reference to the research article 'Styrene exposure and risk of lymphohematopoietic malignancies in 73,036 reinforced plastics workers', published in Epidemiology. Significant improvements have been made to the working environments in the Danish reinforced plastics industry in recent years, but globally the problem has not been solved. This fact sheet is one in a series of summaries about hazardous substances . . wind turbines or yachts. Although some studies suggest that styrene-exposed workers may be at increased cancer risk, the human evidence for styrene carcinogenicity is inconclusive. Styrene - ToxFAQs™ CAS # 100-42-5. 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The reason for different classifications from different organizations is partly a … Exposure-related trend analyses also demonstrated increased risks (P < 0.05) for lymphomas in relation to increases in styrene exposures. Enough already The styrene toxicity database available today provides ample support for a conclusion of “no concern” for styrene and cancer. Elevated risks of lymphohematopoietic cancer were found among workers with higher exposure to styrene after an appropriate elapsed time since first exposure. Four styrene-laden products to ditch. 2 comments . (6) review on behalf of Styrene Information and Research Center, a styrene industry organisation, was presented by co-author P. Cole to the National Toxicology Program’s (NTP) Board of Scientific Counsellors open-to-the-public Peer Review of styrene (7). Aarhus University. But in a time when new studies on cancer links make news weekly, it’s easy to lose sight of the clear and consistent evidence: many common cancers have their roots in lifestyle factors. was a member of the NTP RoC Styrene Expert Panel Meeting, July 2008. It is not intended to provide medical or other professional advice. One example is the monograph, which recently showed that diesel exhaust can cause lung cancer. The European Union undertook a risk assessment of styrene and concluded that, “based on human studies, there is no clear and consistent evidence for a causal link between specific cancer mortality and exposure to styrene” (EU 2008, p. 271). It is important … Oxford University Press is a department of the University of Oxford. Henrik Kolstad emphasizes that the Danish register findings reflect the sins of the past. The Department of Occupational Medicine at Aarhus University in Denmark has concluded that styrene may cause cancer in humans. Philadelphia-negative myeloproliferative neoplasms among Kuwaiti Nationals. Additional evidence for styrene and human cancers is supported by carcinogenesis bioassays as sufficient evidence for the carcinogenicity of styrene in experimental animals based on the induction of tumours in multiple studies in mice exposed to styrene by two routes of exposure. There is sparse and inconsistent evidence of an association between styrene exposure and cancer. 12th Report on Carcinogens, National Toxicology Program, Some traditional herbal medicines, some mycotoxins, naphthalene and styrene, Epidemiologic studies of styrene and cancer: a review of the literature, RE: Request for NTP to Fully Consider New Styrene Epidemiology Review Prior to Finalizing Styrene Draft Substance Profile, 16 Dec 2008, 3 page letter to Wilson SH, NIEHS from Synder J, SIRC. Reddit; Wechat; Abstract. Conflict of interest statement: None declared. This thread is … report. California Health & Safety Code Section 25249.6. Reddit; Founded in 1976 ... the singer has revealed she’s battling breast cancer. After 40 years in limbo: Styrene is probably carcinogenic. We've requested the relevant data in anonymised form from the companies that analyse the measurements , but unfortunately, we were unable to gain access to them," says Henrik Kolstad, "This is deeply regrettable, because the fact is that good answers to important questions presupposes that we also have access to the relevant information in the future.". (6) concluded that the available epidemiologic evidence does not support a causal relationship between styrene exposure and any type of human cancer’ (2). and their health effects. Styrene news and market information products from ICIS. Just this week, the National Research Council (NRC) signed off on the National Toxicology Program’s decision to list styrene … The authors (2) quote correctly that the ‘International Agency for Research on Cancer (IARC) classified styrene as possibly carcinogenic to humans (Group 2B) and SO as probably carcinogenic to humans (Group 2A)’. The reports are prepared by the International Agency for Research on Cancer (IARC), which is one of the WHO's expert bodies. 16 . Styrene and the primary metabolite styrene-7,8-oxide are genotoxic and carcinogenic. For possible other human cancer sites related to styrene exposures, NTP asserts ‘Studies in the reinforced-plastics industry provided evidence that suggests a possible association between styrene exposure and cancer of the esophagus or pancreas.’ (1). The most robust studies are a 2-year inhalation study in CD-1 mice and a 2-year oral gavage study in B6C3F1 mice, showing significantly increased incidences of lung tumours in male and female CD-1 mice, in male B6C3F1 mice and in both sexes of O20 mice (1,11–13). These two papers add to the accumulated evidence linking styrene exposure to human cancers. Benchmark dose analysis of multiple genotoxicity endpoints in, Telomere length in peripheral blood lymphocytes related to genetic variation in telomerase, prognosis and clinicopathological features in breast cancer patients, The effect of chronic dosing and p53 status on the genotoxicity of pro-oxidant chemicals, Detection of urethane-induced genotoxicity. Proposition 65 requires businesses to determine if they must provide a warning about exposure to listed chemicals. (2018, May 30). It furthers the University's objective of excellence in research, scholarship, and education by publishing worldwide, This PDF is available to Subscribers Only. IARC’s (5) evaluation of the available human studies nearly 10 years ago stated ‘There is limited evidence in humans for the carcinogenicity of styrene’, which indicates evidence of a credible but not a clear demonstration of a causal association with lymphatic/hematopoietic neoplasms in humans. This fact sheet answers the most frequently asked health questions (FAQs) about styrene. Ultimately, more emphasis needs to be directed towards primary prevention as the most reliable channel for reducing or eliminating cancer burdens, especially among workers exposed to known carcinogens and mutagens (16,26,27). Styrene officially linked to cancer . Styrene Officially Linked to Cancer Styrene Officially Linked to Cancer. Reasonably Anticipated to Be a Human Carcinogen. 12th Report on Carcinogens, National Toxicology Program, Cytogenetic and DNA damage on workers exposed to styrene, Styrene metabolism, genotoxicity, and potential carcinogenicity, Styrene Oxide CAS No. The scientific effort to describe the potential for styrene exposure to cause cancer in humans may be entering its last phase. Examines mortality patterns in a number of cities has a sweet smell in humans among some styrene … styrene linked. Views expressed here do not necessarily reflect those of ScienceDaily, its staff, its staff, staff... Butadiene or styrene or butadiene and styrene or butadiene and styrene or butadiene and or. A number of cities while EU countries do not necessarily reflect those of ScienceDaily, its staff its! As a carcinogen for increased risk of any cancer among workers exposed to styrene may increase the of... 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Study examines mortality patterns in a series of summaries about hazardous substances four styrene laden products to ditch a...