Adderall XR administration is contraindicated in patients with the following conditions: CNS stimulants, including Adderall XR, other amphetamine-containing products, and methylphenidate, have a high potential for abuse and dependence. Adderall XR® is a registered trademark of Musculoskeletal and Connective Tissue Disorders. Adderall XR. Assess the risk of abuse prior to prescribing and monitor for signs of abuse and dependence while on therapy [see Warnings and Precautions (5.1) and Drug Abuse and Dependence (9.2, 9.3)]. For the Inattentive Type, at least six of the following symptoms must have persisted for at least 6 months: lack of attention to details/careless mistakes; lack of sustained attention; poor listener; failure to follow through on tasks; poor organization; avoids tasks requiring sustained mental effort; loses things; easily distracted; forgetful. All pregnancies have a background risk of birth defect, loss, or other adverse outcomes. Amphetamines are non-catecholamine sympathomimetic amines with CNS stimulant activity. Adderall XR is indicated as an integral part of a total treatment program for ADHD that may include other measures (psychological, educational, social) for patients with this syndrome. Fetal malformations and death have been reported in mice following parenteral administration of d-amphetamine doses of 50 mg/kg/day (approximately 10 times the MRHD given to adolescents on a mg/m2 basis) or greater to pregnant animals. Other measures (e.g., psychological, educational, and social therapies) are used along with mixed salts amphetamine as part of an overall treatment program for ADHD. Do not use Adderall XR for a condition for which it was not prescribed. The lowest GoodRx price for the most common version of generic Adderall is around $15.22, 68% off the average retail price of $47.58. https://www.webmd.com/drugs/2/drug-63164/adderall-xr-oral/details Generic amphetamine salt combo XR is covered by most Medicare and insurance plans, but some pharmacy coupons or cash prices may be lower. Amphetamine is known to inhibit monoamine oxidase, whereas the ability of amphetamine and its metabolites to inhibit various P450 isozymes and other enzymes has not been adequately elucidated. is sensitive to, allergic to, or had a reaction to other stimulant medicines, have heart problems, heart defects, or high blood pressure, have mental problems including psychosis, mania, bipolar illness, or depression, have seizures or have had an abnormal brain wave test (EEG), have circulation problems in fingers and toes. Based on bioequivalence data, patients taking divided doses of immediate-release ADDERALL, (for example, twice daily), may be switched to Adderall XR at the same total daily dose taken once daily. There was not adequate evidence that doses greater than 20 mg/day conferred additional benefit. Controlled Substance Status/Potential for Abuse, Misuse, and Dependence. If such symptoms occur, consideration should be given to a possible causal role of the stimulant, and discontinuation of treatment may be appropriate. A decrease in pup body weight was seen at 6 and 10 mg/kg which correlated with delays in developmental landmarks, such as preputial separation and vaginal opening. The impact of renal impairment on the disposition of amphetamine is expected to be similar between oral administration of lisdexamfetamine and Adderall XR. A study was conducted in which pregnant rats received daily oral doses of amphetamine (d- to l- enantiomer ratio of 3:1) of 2, 6, and 10 mg/kg from gestation day 6 to lactation day 20. Gelatin capsules contain edible inks, kosher gelatin, and titanium dioxide. Because these reactions are reported voluntarily from a population of uncertain size, it is not always possible to reliably estimate their frequency or establish a causal relationship to drug exposure. The symptoms must not be better accounted for by another mental disorder. Children, adolescents, or adults who are being considered for treatment with stimulant medications should have a careful history (including assessment for a family history of sudden death or ventricular arrhythmia) and physical exam to assess for the presence of cardiac disease, and should receive further cardiac evaluation if findings suggest such disease (e.g. This Medication Guide has been approved by the U.S. Food and Drug Administration. In addition, amphetamines can stimulate uterine contractions, increasing the risk of premature delivery. This Medication Guide summarizes the most important information about Adderall XR. Administration of stimulants may exacerbate symptoms of behavior disturbance and thought disorder in patients with pre-existing psychotic disorder. Serotonin syndrome symptoms may include mental status changes (e.g., agitation, hallucinations, delirium, and coma), autonomic instability (e.g., tachycardia, labile blood pressure, dizziness, diaphoresis, flushing, hyperthermia), neuromuscular symptoms (e.g., tremor, rigidity, myoclonus, hyperreflexia, incoordination), seizures, and/or gastrointestinal symptoms (e.g., nausea, vomiting, diarrhea). Adderall XR® Distributed by Takeda Pharmaceuticals America, Inc., Lexington, MA 02421, Made in USA. Monitor for signs of abuse while on therapy and re-evaluate the need for Adderall XR use. Lower blood levels and efficacy of amphetamines. Takeda Pharmaceuticals U.S.A., Inc. Excursions permitted to 15-30º C (59-86ºF) [see USP CONTROLLED ROOM TEMPERATURE]. Adverse Reactions Leading to Discontinuation of Treatment. The elimination half-life (t1/2) is approximately 1 hour shorter for d-amphetamine and 2 hours shorter for l-amphetamine in children than in adults. Tell your doctor about any mental problems you or your child have, or about a family history of suicide, bipolar illness, or depression. Dispense in a tight, light-resistant container. Withdrawal symptoms after abrupt cessation of CNS stimulants include dysphoric mood; fatigue; vivid, unpleasant dreams; insomnia or hypersomnia; increased appetite; and psychomotor retardation or agitation. Adderall XR should be given upon awakening. It is not possible to accurately identify a pill online without an imprint code. It is possible that large dosages of amphetamine might interfere with milk production, especially in women whose lactation is not well established. The 5 mg, 10 mg, 15 mg, 20 mg, 25 mg and 30 mg strength extended release capsules are for oral administration. (Generic for ADDERALL XR) QTY 30 • 20 MG • Capsule ER 24H • Near 77381; Add to Medicine Chest; Set Price Alert; More Ways to Save; AMPHETAMINE; DEXTROAMPHETAMINE (am FET a meen; dex troe am FET a meen) is used to treat attention-deficit hyperactivity disorder (ADHD). This Medication Guide does not take the place of talking to your doctor about you or your child's treatment with Adderall XR. Note: The following reactions did not meet the criterion for inclusion in Table 3 but were reported by 2% to 4% of adult patients receiving Adderall XR with a higher incidence than patients receiving placebo in this study: infection, photosensitivity reaction, constipation, tooth disorder (e.g., teeth clenching, tooth infection), emotional lability, libido decreased, somnolence, speech disorder (e.g., stuttering, excessive speech), palpitation, twitching, dyspnea, sweating, dysmenorrhea, and impotence. 7. Consult with a Certified Poison Control Center for up to date guidance and advice. Adderall XR is a once daily central nervous system stimulant prescription medicine. Medically reviewed by Drugs.com. In pediatric patients (6 to 17 years of age) with severe renal impairment, the recommended dose is 5 mg once daily. Signs and symptoms are usually intermittent and mild; however, very rare sequelae include digital ulceration and/or soft tissue breakdown. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Titrate at weekly intervals to appropriate efficacy and tolerability as indicated. The maximum recommended dose for children 6-12 years of age is 30 mg/day; doses greater than 30 mg/day have not been studied in children. Data sources include IBM Watson Micromedex (updated 7 Dec 2020), Cerner Multum™ (updated 4 Dec 2020), ASHP (updated 3 Dec 2020) and others. Store at room temperature, 20º C to 25º C (68º F to 77º F). Hypersensitivity reactions such as angioedema and anaphylactic reactions have been reported in patients treated with other amphetamine products, Patients taking monoamine oxidase inhibitors (MAOIs), or within 14 days of stopping MAOIs (including MAOIs such as linezolid or intravenous methylene blue), because of an increased risk of hypertensive crisis, have heart disease or hardening of the arteries, have moderate to severe high blood pressure. 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